Browsing by Title
Now showing items 45026-45045 of 63724
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Probabilistic Models for Exploring, Predicting, and Influencing Health Trajectories
(Johns Hopkins UniversityUSA, 2019-10-24)Over the past decade, healthcare systems around the world have transitioned from paper to electronic health records. The majority of healthcare systems today now host large, on-premise clusters that support an institution-wide ... -
Probably Approximately Correct Robust Policy Search with Applications to Mobile Robotics
(Johns Hopkins UniversityUSA, 2020-02-19)This thesis studies the problem of designing reliable control laws of robotic systems operating in uncertain environments. We tackle this issue by using stochastic optimization to iteratively refine the parameters of a ... -
Probing and Overcoming Extracellular Barriers to Inhaled Nanomedicine
(Johns Hopkins UniversityUSA, 2014-08-08)Inhaled nanoparticles are a promising technology for delivering therapeutic molecules to the lungs to treat diseases such as cystic fibrosis (CF) and lung cancer. This dissertation focuses on characterizing and overcoming ... -
Probing Anomalous Couplings of the Higgs Boson to Weak Bosons and Fermions with Precision Calculations
(Johns Hopkins UniversityUSA, 2019-02-21)In this thesis I present a phenomenological study of the Higgs boson anomalous couplings to weak bosons and fermions. I focus on Higgs bosons produced in association with a weak boson ($V \to VH~(V=W^\pm,Z)$) at hadron ... -
PROBING COSMOLOGY AT DIFFERENT SCALES
(Johns Hopkins UniversityUSA, 2019-10-15)Although we are in an era of precision cosmology, there is still much about our Universe that we do not know. Moreover, the concordance ΛCDM model of cosmology faces many challenges at all scales relevant to cosmology. ... -
Probing lipoylation in Plasmodium
(Johns Hopkins UniversityUSA, 2018-04-26)The malaria parasite, Plasmodium spp., uses the lipoate cofactor in two of its organelles: the apicoplast and the mitochondion. The apicoplast of the parasite uses an endogenous, biosynthetic pathway to lipoylate its ... -
Probing mechanisms of genome maintenance using single molecule methods
(Johns Hopkins UniversityUSA, 2021-11-24)The maintenance of DNA integrity is a highly involved and regulated process, requiring the coordination of various proteins and DNA, and their interactions. Advancements in fluorescence and optical microscopy techniques ... -
Probing native macromolecular complexes using single-molecule pull-down
(Johns Hopkins UniversityUSA, 2017-02-01)Macromolecular complexes consisting of proteins, lipids, and/ or nucleic acids are ubiquitous in biological processes. Their composition, stoichiometry, order of assembly, and conformations can be heterogeneous or can ... -
Probing new physics using Initial State Radiation Jets at the Large Hadron Collider
(Johns Hopkins UniversityUSA, 2020-07-15)The existence of new particles and interactions could potentially address fundamental questions about our universe, for example, the nature of dark matter. If dark matter couples, even feebly, to the Standard Model, then ... -
PROBING PROTEIN-NUCLEIC ACID INTERACTIONS WITH OPTICAL MANIPULATION
(Johns Hopkins UniversityUSA, 2019-08-19)Studies of protein-nucleic acid interactions have received much attention and have revealed the sophisticated control of complicated bio-molecular systems within the cell. Among them, the careful regulation of single-stranded ... -
PROBING THE DYNAMICS OF RNA POLYMERASE AND HU IN LIVE E. COLI CELLS
(Johns Hopkins UniversityUSA, 2019-04-10)Diffusion is at the heart of every biochemical process. Millions of proteins must navigate the heterogeneous, crowded cellular milieu to perform their various tasks. This molecular crowding has a significant effect on the ... -
PROBING THE ELECTRONIC PROPERTIES OF INTRAMOLECULAR PROTON TRANSFER, TRIPLE RYDBERG ANIONS, AND STABLE RADICALS VIA ANION PHOTOELECTRON SPECTROSCOPY
(Johns Hopkins UniversityUSA, 2019-01-22)Negative ions were studied using gas-phase anion photoelectron spectroscopy. Combining these studies with theoretical calculations allowed for electronic properties, geometries, as well as chemical phenomena to be ... -
PROBING THE REFOLDABILITY OF THE SACCHAROMYCES CEREVISIAE TRANSCRIPTOME
(Johns Hopkins UniversityUSA, 2022-04-15)Anfinsen’s Dogma1,2 states that a protein’s native structure is strictly determined by its primary amino acid sequence, and as such, a protein that is unfolded should be able to find its way back to its native structure. ... -
The Problem With “Finding the Main Idea”
(Johns Hopkins Institute for Education Policy and Learning First, 2019-01-01) -
The Problems and Challenges of Research and Writing on Africans and their Descendants in Colonial Cartagena de Indies:A Research Report
(Center for Africana Studies, 2007)This paper is a work-in-progress summarizing the kinds of documents that can be used to learn about the history of Africans in colonial Cartagena de Indias. Some of the sources described here include the work of Alonso ... -
Problems at Work
(Johns Hopkins UniversityUSA, 2016-03-23)A collection of stories. Thesis director: Brad Leithauser; second reader: Greg Williamson. -
PROBLEMS OF CITY MANAGEMENT AND ECOLOGICALLY SUSTAINABLE CITY ENVIRONMENTS
(Intsitute for Policy Studies, Johns Hopkins University, 1992-05) -
PROBLEMS OF CONTEMPORARY DEVELOPMENTS IN AMSTERDAM
(Intstitute for Policy Studies, Johns Hopkins University, 1973) -
Problems of mysticism and its symbolism,
(Moffat, Yard and company,, 1917.) -
Proceedings and Summary of the 2020 CFSRC Colloquium
(2020-10-22)With 110 concurrent attendees from 15 time zones and 51 papers and talks the global online Colloquium held from 20-21 October 2020 provided a unique forum for sharing and learning about the latest research and innovations ...