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USING THE TS65DN MOUSE MODEL OF DOWN SYNDROME TO UNDERSTAND THE GENETICS OF CONGENITAL HEART DEFECTS
(Johns Hopkins University, 2014-03-21)Down syndrome (DS) is the most common chromosomal abnormality in humans, caused by having three copies of human chromosome 21 (Hsa21). It is associated with a variety of features affecting almost every organ system, including ... -
Using Transportation Distances for Measuring Melodic Similarity
(Johns Hopkins University, 2003-10-26)Most of the existing methods for measuring melodic similarity use one-dimensional textual representations of music notation, so that melodic similarity can be measured by calculating editing distances. We view notes as ... -
USING VINCULIN MUTANTS TO ASCERTAIN THE ROLE OF VINCULIN IN CELLULAR MOTILITY AND MECHANOTRANSDUCTION
(Johns Hopkins University, 2014-02-18)Vinculin is a 117kDa soluble cytoplasmic protein that localizes to focal adhesions. Biochemical studies show that vinculin tail binds actin and vinculin head binds talin. These ligand binding interactions imply a role for ... -
Using Whole Exome Sequencing for Familial Inflammatory Bowel Disease
(Johns Hopkins UniversityUSA, 2020-04-17)Inflammatory Bowel Disease (IBD), which includes both ulcerative colitis and Crohn’s disease, is characterized by chronic relapsing gastrointestinal inflammation and afflicts at least 1.4 million people in United States. ... -
USMG Update
(2021-06-07) -
USS Santa Olivia
(Johns Hopkins University Sheridan Libraries, 1918)Caption: Settling it; troops, USS Santa Olivia, Bing; the gunner. Navy troops are aboard the USS Santa Olivia watching a boxing fight between two soldiers. -
Utility of Quantitative Analysis in Drug Development and Optimization of Anti-Infective Therapy
(Johns Hopkins UniversityUSA, 2015-12-15)The cornerstone of anti-infective therapy is attainment of the effective target concentration of the drug at the site of infection; achieving this goal requires integration of the pharmacokinetic and pharmacodynamics ... -
The Utility's Transformation to a Smart City Platform Provider
(2018-05)The concept of Smart Cities is pervasive when contemplating emerging energy trends and opportunities. And increasingly, large cities and municipalities are moving forward with sustainability objectives which are decidedly ... -
Utility-Scale Fixed-Tilt PV vs. Single-Axis Tracker PV: Nems Projections to 2050
(2018-04)The main purpose of this National Energy Modeling System (NEMS) project was to investigate the cost and performance tradeoffs of utility-scale solar PV through modeling variations in fixed-tilt and single-axis tracker ... -
Utility-Scale Solar Construction: Best Practices for Reducing Costs and Ensuring Environmental Compliance
(2019-12)The environmental benefits of solar power are well known as an energy source that emits minimal greenhouse gases during operation, but there are environmental risks to address during and after construction that cannot be ... -
UTILIZATION AND OUTCOMES OF WARFARIN AMONG PATIENTS WITH END STAGE RENAL DISEASE AND ATRIAL FIBRILLATION
(Johns Hopkins UniversityUSA, 2016-10-03)Background: Patients with end stage renal disease (ESRD) and atrial fibrillation (AF), particularly older adults on dialysis, are at elevated risk for stroke-related morbidity, mortality, and bleeding. There is conflicting ... -
UTILIZATION CONTROLS FOR ORPHAN DRUGS: PRIOR AUTHORIZATION DOES NOT CORRELATE WITH LOWER DRUG USE
(Johns Hopkins UniversityUSA, 2020-04-17)Background: While 7 of the top selling drugs in the U.S. have orphan status, 95% of 7000 rare diseases still lack treatments. With the growing number of expensive orphan drugs in the market, insurers have increasingly ... -
UTILIZATION OF A NOVEL WEB-BASED TOOL TO STUDY GENETIC COUNSELOR COMMUNICATION
(Johns Hopkins UniversityUSA, 2017-02-02)Objective: Communication has been shown to be an important aspect of healthcare. This thesis aims to explore a new method of studying genetic counselor communication as well as further describe genetic counselor communication ... -
Utilization of Hydrilla verticillata by wintering waterfowl on the tidal Potomac River
(Advanced Academic Programs, The Johns Hopkins University, 2008-05) -
The Utilization of Informal Financing to Accelerate Off-Grid Energy Adoption in Kenya's Rural Areas
(2020-05)The research paper provides a literature review and analysis on the role of informal financing in the adoption of renewable off-grid technologies and the electrification of Kenya’s rural areas. The country is facing a ... -
UTILIZATION OF SOLUBLE RECEPTOR BINDING PROTEINS TO CHARACTERIZE MOLECULAR AND PHENOTYPIC FEATURES OF MEMORY B CELL AND NEUTRALIZING ANTIBODY RESPONSES IN HEPATITIS C VIRUS OR SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 INFECTION
(Johns Hopkins UniversityUSA, 2022-02-14)A goal of vaccines is to elicit a durable memory B cell response that can be recalled upon during infection. During viral infections, B- and T-cell memory responses develop against structural and nonstructural virion ... -
UTILIZING A DYNAMICAL SYSTEM MODEL TO UNCOVER NON-CONVENTIONAL DRIVERS IN COUPLED MOTOR CORTICES
(Johns Hopkins UniversityUSA, 2021-03-17)In the conventional view of sensorimotor control, the premotor cortex (PM) plans actions that are executed by the primary motor cortex (M1). This notion arises in part from many experiments that have imposed a preparatory ... -
Utilizing Metabolic Analysis to Characterize the Metabolism of Mammalian Cells
(Johns Hopkins UniversityUSA, 2018-10-26)The focus of this project is to study metabolism in cancer and Chinese hamster ovary (CHO) cells. Cancer is one of the deadliest diseases worldwide, but treatment options are often limited and outlooks bleak. Studying ... -
Utilizing Nanotechnology for Disease Severity Assessment and Drug Delivery in Chronic Obstructive Pulmonary Disease
(Johns Hopkins UniversityUSA, 2017-10-27)Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death in the United States with continuously elevating morbidity and mortality. COPD is a complex progressive disease primarily caused ... -
Utilizing nanotechnology to improve the activation of CD8 T cells for cancer immunotherapy
(Johns Hopkins UniversityUSA, 2018-03-15)The immune system can be manipulated to recognize and eliminate cancerous cells. Many of these manipulations aim to increase the proliferation and activation of tumor-targeting cytotoxic CD8+ T cells through direct stimulation ...