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    • MODELING AND THERAPEUTIC TARGETING OF ENDOGENOUS IDH1-MUTANT GLIOMA 

      Borodovsky, Alexandra (Johns Hopkins UniversityUSA, 2014-03-21)
      Somatic mutations in Isocitrate Dehydrogenase 1 (IDH1) are frequent in low grade and progressive gliomas. IDH1 mutant tumors are phenotypically characterized by the increased production of 2-hydroxyglutarate (2-HG) from ...