Now showing items 1-5 of 5

    • Adjustment Procedure to Permutation Tests in Epigenomic Differential Analysis 

      Jiang, Dan (Johns Hopkins UniversityUSA, 2017-09-06)
      In the analysis of genomic data, t-statistics are widely used to detect differential signals between different groups of samples. In many studies, each group has only a small number of replicate samples, making the variance ...
    • FCAT: A FLEXIBLE CLASSIFICATION TOOLBOX FOR SIGNAL DETECTION IN HIGH-THROUGHPUT SEQUENCING DATA 

      He, Bing (Johns Hopkins UniversityUSA, 2017-04-03)
      As applications of high-throughput sequencing technologies continue to grow at a fast rate, being able to conveniently develop effective data analysis solutions that can take full advantage of application-specific data ...
    • SPATIOTEMPORAL REGULATION OF CAMP/PKA SIGNALING IN CELLULAR PROCESSES 

      Yang, Jessica R. (Johns Hopkins UniversityUSA, 2015-08-12)
      Cells respond to extracellular stimuli by modulating intricately intertwined signaling pathways. To achieve specific responses, these pathways are tightly controlled in space and time by regulating second messenger ...
    • Transcription factor binding motif analyses in two biological systems 

      Zhang, Shilu (Johns Hopkins University, 2014-04-25)
      The mechanism of gene regulation is a crucial problem in current computational biology. Chromatin-immunoprecipitation microarray (ChIP-chip) is a technique used to study transcriptional regulation by identifying the binding ...
    • Using Protein Microarrays to Profile Human PTMs 

      Neiswinger, Johnathan Philip (Johns Hopkins UniversityUSA, 2014-03-25)
      Over the last quarter century, protein microarray technology has emerged as a prominent field in scientific study. The versatility of the platform, coupled with the ability to characterize thousands of proteins in a ...