Relationship of somatosensory evoked potentials and cerebral oxygen consumption during hypoxic hypoxia in dogs

Show full item record

Title: Relationship of somatosensory evoked potentials and cerebral oxygen consumption during hypoxic hypoxia in dogs
Author: Traystman, R.J.; Zeger, Scott L.; McPherson, R.W.
Abstract: The effects of hypoxic hypoxia on cerebral hemodynamics and somatosensory evoked potential (SEP) were studied in 10 pentobarbital anestheteized dogs. Cerebral blood flow (CBF) was measured using the venous outflow technique and cerebral oxygen consumption (CMRO2) was calculated from the arterio-cerebro-venous oxygen difference times CBF. SEP was evaluated by percutaneous stimulation of an upper extremity nerve and was recorded over the contralateral somatosensory cortex. The latencies of the initial negative wave (N1), second positive wave (P2) and the amplitude of the primary complex (P1N1) were measured. Animals were breathed sequentially with oxygen concentrations of 21, 10, 6, 5, and 4.5% for five minutes each. Animals were returned to room air breathing when the amplitude of the SEP decreased to less than 20% of control and were observed for 30 minutes following reoxygenation. Severe hypoxia (4.5% O2) increased CBF to 200% of control, decreased CMRO2 to 45% of control, decreased amplitude and increased latency of SEP. Following reoxygenation, as CMRO2 increased toward control, latency of SEP decreased and amplitude increased and CBF returned to baseline within 30 min. During hypoxia and reoxygenation, the latencies of N1 and P2 and the amplitude of P1N1 were correlated with CMRO2 in individual animals. We conclude that changes in SEP amplitude and latency reflect changes in CMRO2 despite high CBF during rapidly progressive hypoxic hypoxia and following reoxygenation.
URI: http://jhir.library.jhu.edu/handle/1774.2/32865
Date: 1986
Citation: McPherson, R.W., Scott L. Zeger and RJ Traystman. "Relationship of somatosensory evoked potentials and cerebral oxygen consumption during hypoxic hypoxia in dogs" Stroke 17 (1986):30-36 http://stroke.ahajournals.org/cgi/content/abstract/17/1/30?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=zeger&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Subject: Cerebral hemodynamics
Hypoxic hypoxia
Somatosensory evoked potentials

Files in this item

Files Size Format Download
1986-RelationshipSomatosensory.pdf 759.6Kb application/pdf Download

The following license files are associated with this item:

This item appears in the following Collection(s)

Show full item record