Now showing items 1-2 of 2

    • Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice 

      DePinho, Ronald A.; Greider, Carol W.; Gottlieb, Geoffrey J.; Blasco, Maria; Lee, Han-Woong; Chang, Sandy; Rudolph, Karl Lenhard (Cell Press, 1999-03-05)
      Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the ...
    • Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA 

      Greider, Carol W.; DePinho, Ronald A.; Lansdorp, Peter M.; Semper, Enrique; Hande, M. Prakash; Lee, Han-Woong; Blasco, Maria A. (Cell Press, 1997-10-03)
      To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six ...