Now showing items 1-4 of 4

    • An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain 

      Traystman, R J; Haug, F M; Agre, P; Amiry-Moghaddam, M; Froehner, S C; Adams, M E; Hurn, P D; Ottersen, O P; Otsuka, T; Neely, J D; Bhardwaj, A (National Academy of Sciences, 2003-02-18)
      The water channel AQP4 is concentrated in perivascular and subpial membrane domains of brain astrocytes. These membranes form the interface between the neuropil and extracerebral liquid spaces. AQP4 is anchored at these ...
    • Aquaporin-4 square array assembly: Opposing actions of M1 and M23 isoforms 

      Rash, J E; Agre, P; Neely, J D; Yasumura, T; Davidson, K G; Gorelick-Feldman, D A; Furman, C S (National Academy of Sciences, 2003-11-11)
      Osmotic homeostasis in the brain involves movement of water through aquaporin-4 (AQP4) membrane channels. Perivascular astrocyte end-feet contain distinctive orthogonal lattices (square arrays) assembled from 4- to 6-nm ...
    • Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice 

      Nielsen, S; Frøkiaer, J; Agre, P; Neely, J D; Dóczi, T; Sulyok, E; Stødkilde-Jørgensen, H; Wertz, K; Füchtbauer, E M; Pedersen, M; Vajda, Z (National Academy of Sciences, 2002-10-01)
      Cerebral water accumulation was studied during induction of brain edema in dystrophin-null transgenic mice (mdx-betageo) and control mice. Immunofluorescence and immunoelectron microscopic analyses of dystrophin-null brains ...
    • Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein 

      Adams, M E; Agre, P; Froehner, S C; Ottersen, O P; Amiry-Moghaddam, M; Neely, J D (National Academy of Sciences, 2001-11-20)
      The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyte endfeet where it is concentrated. We postulated that AQP4 is tethered at this site by binding of the AQP4 C terminus to ...