Now showing items 1-3 of 3
Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro
(Oxford University Press, 1998-02-01)
Telomere-specific repeat sequences are essential for chromosome end stability. Telomerase maintains telomere length by adding sequences de novo onto chromosome ends. The template domain of the telomerase RNA component ...
Short telomeres induce a DNA damage response in Saccharomyces cerevisiae
(American Society for Cell Biology, 2003-03)
Telomerase-deficient Saccharomyces cerevisiae cells show a progressive decrease in telomere length. When grown for several days in log phase, the tlc1Delta cells initially display wild-type growth kinetics with subsequent ...
Telomerase mutations in families with idiopathic pulmonary fibrosis
(Massachusetts Medical Society, 2007-03-29)
BACKGROUND: Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase ...