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Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. II. Determination of molecular genetic origins of rearrangements
(American Society for Clinical Investigation, 1990-08)
Protein 4.1 is an approximately 80-kD structural protein in the membrane skeleton which underlies and supports the erythrocyte plasma membrane. The preceding companion paper presents a biochemical study of two abnormal ...
Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes
(American Society for Biochemistry and Molecular Biology, 1983-05-25)
This report describes Ca2+-dependent binding of 125I-labeled calmodulin (125I-CaM) to erythrocyte membranes and identification of two new CaM-binding proteins. Erythrocyte CaM labeled with 125I-Bolton Hunter reagent fully ...
The human Aquaporin-5 gene. Molecular characterization and chromosomal localization.
(American Society for Biochemistry and Molecular Biology, 1996-04-12)
The cDNA for the fifth mammalian aquaporin (AQP5) was isolated from rat, and expression was demonstrated in rat salivary and lacrimal glands, cornea, and lung (Raina, S., Preston, G. M., Guggino, W. B., and Agre, P. (1995) ...
Quantification of Aquaporin-CHIP water channel protein in microdissected renal tubules by fluorescence-based ELISA
(American Society for Clinical Investigation, 1995-01)
Several transporters have been localized along the nephron by physiological methods or immunocytochemistry. However, the actual abundance of these molecules has not been established. To accomplish this goal, we have developed ...
The Rh polypeptide is a major fatty acid-acylated erythrocyte membrane protein
(American Society for Biochemistry and Molecular Biology, 1988-12-05)
The erythrocyte Rh antigens contain an Mr = 32,000 integral protein which is thought to contribute in some way to the organization of surrounding phospholipid. To search for possible fatty acid acylation of the Rh polypeptide, ...
Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine
(American Society for Clinical Investigation, 2002-06-01)
Molecular Cloning and Characterization of an Aquaporin cDNA from Salivary, Lacrimal, and Respiratory Tissues
(American Society for Biochemistry and Molecular Biology, 1995-01-27)
The Aquaporin family of water channels plays a fundamental role in transmembrane water movements in numerous plant and animal tissues. Since the molecular pathway by which water is secreted by salivary glands is unknown, ...
Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens
(American Society for Clinical Investigation, 1994-09)
Blood group antigens are structural variants in surface carbohydrate or amino acid polymorphisms on extracellular domains of membrane proteins. The red cell water channel-forming integral protein (Aquaporin CHIP) is a ...
A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin
(American Society for Clinical Investigation, 1981-12)
Patients from two families with chronic hemolytic anemia have been studied. The erythrocytes are very fragile and appear microcytic with a great variety of shapes. Clinical evaluation failed to identify traditionally ...
Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia
(National Academy of Sciences, 1999-05-01)
All characterized mammalian aquaporins (AQPs) are localized to plasma membranes where they function chiefly to mediate water transport across cells. Here we show that AQP6 is localized exclusively in intracellular membranes ...