Now showing items 1-10 of 30
Phosphorylation of H2AX at short telomeres in T cells and fibroblasts
(American Society for Biochemistry and Molecular Biology, 2004-10-22)
Eukaryotic cells undergo arrest and enter apoptosis in response to short telomeres. T cells from late generation mTR(-/-) mice that lack telomerase show increased apoptosis when stimulated to enter the cell cycle. The ...
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis
(American Association of Cancer Research, 2003-12-01)
To examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These mice exhibited increased germ cell death and chromosome fusions ...
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues
(American Association of Cancer Research, 1996-02-01)
Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and from many tumor adjacent tissue samples. With the recently cloned ...
Telomere dysfunction triggers developmentally regulated germ cell apoptosis
(American Society for Cell Biology, 2001-07)
Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper ...
Purification of Tetrahymena Telomerase and Cloning of Genes Encoding the Two Protein Components of the Enzyme
(Cell Press, 1995-06-02)
Telomerase is a ribonucleoprotein DNA polymerase that catalyzes the de novo synthesis of telomeric simple sequence repeats. We describe the purification of telomerase and the cloning of cDNAs encoding two protein subunits ...
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
(Cell Press, 1999-03-05)
Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the ...
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
(Cell Press, 2005-12-16)
Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/ÿ mice on the CAST/EiJ background, which has short ...
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
(Cell Press, 1997-10-03)
To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six ...
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
(Cell Press, 2001-10-05)
Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR/ G6 mice that have short telomeres with mice ...