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    The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence 

    Herr, Winship; Greider, Carol W.; Villeponteau, Bryant; Feng, Junli; Funk, Walter D.; Blasco, Maria A.; Hinckley, Craig S. (Oxford University Press, 1998-01-15)
    Telomerase is a ribonucleoprotein enzyme with an essential RNA component. Embedded within the telomerase RNA is a template sequence for telomere synthesis. We have characterized the structure of the 5' regions of the human ...
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    Identification of a Specific Telomere Terminal Transferase Activity in Tetrahymena Extracts 

    Blackburn, Elizabeth H.; Greider, Carol W. (Cell Press, 1985-12)
    We have found a novel activity in Tetrahymena cell free extracts that adds tandem TTGGGG repeats onto synthetic telomere primers. The single-stranded DNA oligonucleotides (TTGGGG)4 and TGTGTGGGTGTGTGGGTGTGTGGG, consisting ...
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    Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis 

    Armanios, Mary; Qi, Ling; Strong, Margaret A.; Karim, Baktiar O.; Greider, Carol W.; Huso, David L. (American Association of Cancer Research, 2003-12-01)
    To examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These mice exhibited increased germ cell death and chromosome fusions ...
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    Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues 

    Shay, Jerry W.; Avilion, Ariel A.; Piatyszek, Mieczyslaw A.; Gupta, Jyothi; Greider, Carol W.; Bacchetti, Silvia (American Association of Cancer Research, 1996-02-01)
    Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and from many tumor adjacent tissue samples. With the recently cloned ...
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    Phosphorylation of H2AX at short telomeres in T cells and fibroblasts 

    Greider, Carol W.; Strong, Margaret A.; Hao, Ling-Yang (American Society for Biochemistry and Molecular Biology, 2004-10-22)
    Eukaryotic cells undergo arrest and enter apoptosis in response to short telomeres. T cells from late generation mTR(-/-) mice that lack telomerase show increased apoptosis when stimulated to enter the cell cycle. The ...
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    Tracking Telomerase 

    Blackburn, Elizabeth H.; Greider, Carol W. (2004-01-23)
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    Telomere dysfunction triggers developmentally regulated germ cell apoptosis 

    Greider, Carol W.; Chin, Lynda; DePinho, Ronald A.; Strong, Margaret A.; Rudolph, Karl Lenhard; Hemann, Michael T. (American Society for Cell Biology, 2001-07)
    Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper ...
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    Purification of Tetrahymena Telomerase and Cloning of Genes Encoding the Two Protein Components of the Enzyme 

    Greider, Carol W.; Kobayashi, Ryuji; Collins, Kathleen (Cell Press, 1995-06-02)
    Telomerase is a ribonucleoprotein DNA polymerase that catalyzes the de novo synthesis of telomeric simple sequence repeats. We describe the purification of telomerase and the cloning of cDNAs encoding two protein subunits ...
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    Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice 

    DePinho, Ronald A.; Greider, Carol W.; Gottlieb, Geoffrey J.; Blasco, Maria; Lee, Han-Woong; Chang, Sandy; Rudolph, Karl Lenhard (Cell Press, 1999-03-05)
    Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the ...
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    Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity 

    Greider, Carol W.; Huso, David; Feldser, David M.; Karim, Baktiar; Strong, Margaret A.; Armanios, Mary; Hao, Ling-Yang (Cell Press, 2005-12-16)
    Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/ÿ mice on the CAST/EiJ background, which has short ...
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    Greider, Carol W. (30)
    DePinho, Ronald A. (5)Strong, Margaret A. (5)Blasco, Maria A. (4)Hemann, Michael T. (4)Blackburn, Elizabeth H. (3)Chin, Lynda (3)Feldser, David M. (3)Gottlieb, Geoffrey J. (3)Hao, Ling-Yang (3)... View MoreSubjectTelomerase/metabolism (9)RNA/metabolism (5)Telomerase/genetics (5)Telomere/physiology (5)Telomere/genetics (4)DNA Nucleotidylexotransferase /metabolism (3)Telomerase/deficiency (3)Tetrahymena/enzymology (3)Base Sequence (2)Cell Transformation, Neoplastic (2)... View MoreDate Issued2000 - 2007 (14)1990 - 1999 (14)1985 - 1989 (2)Has File(s)Yes (30)

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