Now showing items 1-10 of 59
Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine
(American Society for Clinical Investigation, 2002-06-01)
Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus
(National Academy of Sciences, 2005-01-25)
An abnormal accumulation of extracellular K+ in the brain has been implicated in the generation of seizures in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis. Experimental studies have shown ...
Targeted disruption of the Cl−/HCO3− exchanger Ae2 results in osteopetrosis in mice
(National Academy of Sciences, 2009-02-03)
Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining calcium homeostasis. The osteoclast creates an enclosed space, a lacuna, between their ruffled ...
Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein
(National Academy of Sciences, 2001-11-20)
The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyte endfeet where it is concentrated. We postulated that AQP4 is tethered at this site by binding of the AQP4 C terminus to ...
Defective Urinary Concentrating Ability Due to a Complete Deficiency of Aquaporin-1
(Massachusetts Medical Society, 2001-07-19)
Aquaporin-1, the archetypal water-channel protein,1 was initially identified in red cells and renal proximal tubular epithelium.2 The gene for aquaporin-1 (AQP1) on chromosome 7 colocalizes with the Colton blood-group ...
Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome
Dry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of aquaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's ...
Structural determinants of water permeation through aquaporin-1
(Nature Publishing Group, 2000-10-05)
Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. Here we describe an atomic model of AQP1 at 3.8A resolution from electron crystallographic data. Multiple ...
Hypertonic induction of aquaporin-5 expression through an ERK-dependent pathway
(American Society for Biochemistry and Molecular Biology, 2000-03-24)
Aquaporin-5 (AQP5) is a water channel protein expressed in lung, salivary gland, and lacrimal gland epithelia. Each of these sites may experience fluctuations in surface liquid osmolarity; however, osmotic regulation of ...
Aquaporins in Saccharomyces: Characterization of a second functional water channel protein
(National Academy of Sciences, 2001-01-30)
The Saccharomyces cerevisiae genome database contains two ORFs with homology to aquaporins, AQY1 and AQY2. Aqy1p has been shown to be a functional aquaporin in some strains, such as Sigma1278b. AQY2 is disrupted by a stop ...
Aquaporin water channels [Nobel Lecture]
(Gesellschaft Deutscher Chemiker, 2004)