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    Phosphorylation of H2AX at short telomeres in T cells and fibroblasts 

    Greider, Carol W.; Strong, Margaret A.; Hao, Ling-Yang (American Society for Biochemistry and Molecular Biology, 2004-10-22)
    Eukaryotic cells undergo arrest and enter apoptosis in response to short telomeres. T cells from late generation mTR(-/-) mice that lack telomerase show increased apoptosis when stimulated to enter the cell cycle. The ...
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    Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity 

    Greider, Carol W.; Huso, David; Feldser, David M.; Karim, Baktiar; Strong, Margaret A.; Armanios, Mary; Hao, Ling-Yang (Cell Press, 2005-12-16)
    Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/ÿ mice on the CAST/EiJ background, which has short ...
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    The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability 

    Greider, Carol W.; Hao, Ling-Yang; Strong, Margaret A.; Hemann, Michael T. (Cell Press, 2001-10-05)
    Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR􏰀/􏰀 G6 mice that have short telomeres with mice ...

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    Author
    Greider, Carol W. (3)
    Hao, Ling-Yang (3)
    Strong, Margaret A. (3)Armanios, Mary (1)Feldser, David M. (1)Hemann, Michael T. (1)Huso, David (1)Karim, Baktiar (1)SubjectCell Survival (1)Chromosomes/physiology (1)DNA/chemistry (1)Intestines/pathology (1)Phosphorylation (1)Telomerase/genetics (1)Telomerase/metabolism (1)Telomere/metabolism (1)Telomere/physiology (1)Telomere/ultrastructure (1)... View MoreDate Issued2001 (1)2004 (1)2005 (1)Has File(s)Yes (3)

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