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    Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis 

    Armanios, Mary; Qi, Ling; Strong, Margaret A.; Karim, Baktiar O.; Greider, Carol W.; Huso, David L. (American Association of Cancer Research, 2003-12-01)
    To examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These mice exhibited increased germ cell death and chromosome fusions ...
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    Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA 

    Greider, Carol W.; DePinho, Ronald A.; Lansdorp, Peter M.; Semper, Enrique; Hande, M. Prakash; Lee, Han-Woong; Blasco, Maria A. (Cell Press, 1997-10-03)
    To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six ...

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    Author
    Greider, Carol W. (2)
    Armanios, Mary (1)Blasco, Maria A. (1)DePinho, Ronald A. (1)Hande, M. Prakash (1)Huso, David L. (1)Karim, Baktiar O. (1)Lansdorp, Peter M. (1)Lee, Han-Woong (1)Qi, Ling (1)... View MoreSubject
    Cell Transformation, Neoplastic (2)
    Experimental/pathology (1)Neoplasms (1)RNA/physiology (1)Telomerase/deficiency (1)Telomerase/physiology (1)Telomere/genetics (1)Telomere/physiology (1)Tumor Suppressor Proteins (1)... View MoreDate Issued1997 (1)2003 (1)Has File(s)Yes (2)

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