Now showing items 1-6 of 6
A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA
(Oxford University Press, 2002-01-15)
Telomerase is an enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The telomerase ribonucleoprotein complex consists of two essential components, a reverse transcriptase and ...
Identification of two RNA-binding proteins associated with human telomerase RNA
(American Society for Cell Biology, 2000-03)
Telomerase plays a crucial role in telomere maintenance in vivo. To understand telomerase regulation, we have been characterizing components of the enzyme. To date several components of the mammalian telomerase holoenzyme ...
Short telomeres induce a DNA damage response in Saccharomyces cerevisiae
(American Society for Cell Biology, 2003-03)
Telomerase-deficient Saccharomyces cerevisiae cells show a progressive decrease in telomere length. When grown for several days in log phase, the tlc1Delta cells initially display wild-type growth kinetics with subsequent ...
Telomerase mutations in families with idiopathic pulmonary fibrosis
(Massachusetts Medical Society, 2007-03-29)
BACKGROUND: Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase ...
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
(Cell Press, 2001-10-05)
Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR/ G6 mice that have short telomeres with mice ...