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The human Aquaporin-5 gene. Molecular characterization and chromosomal localization.
(American Society for Biochemistry and Molecular Biology, 1996-04-12)
The cDNA for the fifth mammalian aquaporin (AQP5) was isolated from rat, and expression was demonstrated in rat salivary and lacrimal glands, cornea, and lung (Raina, S., Preston, G. M., Guggino, W. B., and Agre, P. (1995) ...
Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome
(Elsevier, 2001-06-23)
Dry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of aquaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's ...
Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat
(American Physological Society, 1997-11)
Developmental expression of aquaporin water transport proteins is not well understood in respiratory tract or secretory glands; here we define aquaporin protein ontogeny in rat. Expression of aquaporin-3 (AQP3), AQP4, and ...
Hypertonic induction of aquaporin-5 expression through an ERK-dependent pathway
(American Society for Biochemistry and Molecular Biology, 2000-03-24)
Aquaporin-5 (AQP5) is a water channel protein expressed in lung, salivary gland, and lacrimal gland epithelia. Each of these sites may experience fluctuations in surface liquid osmolarity; however, osmotic regulation of ...
Regulation of the Escherichia coli water channel gene aqpZ
(National Academy of Sciences, 1998-03-31)
Osmotic movement of water across bacterial cell membranes is postulated to be a homeostatic mechanism for maintaining cell turgor. The molecular water transporter remained elusive until discovery of the Escherichia coli ...
Adenovirus-mediated Expression of Aquaporin-5 in Epithelial Cells
(American Society for Biochemistry and Molecular Biology, 1996-09-06)
A recombinant adenovirus coding for rat aquaporin-5 was constructed and plaque purified. The recombinant adenovirus (AdrAQP5) mediated the expression of aquaporin-5 in rat and human salivary cell lines and in dog kidney ...
Highly selective water channel activity measured by voltage clamp: Analysis of planar lipid bilayers reconstituted with purified AqpZ
(National Academy of Sciences, 2001-08-14)
Aquaporins are membrane channels selectively permeated by water or water plus glycerol. Conflicting reports have described ion conductance associated with some water channels, raising the question of whether ion conductance ...
Genomic organization and developmental expression of aquaporin-5 in lung
(American College of Chest Physicians, 1997-06)
Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5
(American Thoracic Society, 1998-04)
We investigated the role of keratinocyte growth factor (KGF) in regulation of alveolar epithelial cell (AEC) phenotype in vitro. Effects of KGF on cell morphology, expression of surfactant apoproteins A, B, and C (SP-A, ...
Functional requirement of aquaporin-5 in plasma membranes of sweat glands
(National Academy of Sciences, 2002-01-08)
The distribution and function of aquaporins (AQPs) have not previously been defined in sweat glands. In this study, AQP1, AQP3, and AQP5 mRNA were demonstrated in rat paw by reverse transcription (RT)-PCR, but AQP2 and ...