Now showing items 1-3 of 3
Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro
(Oxford University Press, 1998-02-01)
Telomere-specific repeat sequences are essential for chromosome end stability. Telomerase maintains telomere length by adding sequences de novo onto chromosome ends. The template domain of the telomerase RNA component ...
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
(Cell Press, 1999-05-14)
Maintenance of telomere length is predicted to be essential for bypass of senescence and crisis checkpoints in cancer cells. The impact of telomere dysfunction on tumorigenesis was assessed in successive generations of ...
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues
(American Association of Cancer Research, 1996-02-01)
Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and from many tumor adjacent tissue samples. With the recently cloned ...