Now showing items 1-3 of 3
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues
(American Association of Cancer Research, 1996-02-01)
Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and from many tumor adjacent tissue samples. With the recently cloned ...
A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA
(Oxford University Press, 2002-01-15)
Telomerase is an enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The telomerase ribonucleoprotein complex consists of two essential components, a reverse transcriptase and ...
Identification of two RNA-binding proteins associated with human telomerase RNA
(American Society for Cell Biology, 2000-03)
Telomerase plays a crucial role in telomere maintenance in vivo. To understand telomerase regulation, we have been characterizing components of the enzyme. To date several components of the mammalian telomerase holoenzyme ...