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    Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. 

    DePinho, Ronald A.; Greider, Carol W.; Singer, Robert H.; Gottlieb, Geoffrey J.; Lee, Kee-Ho; Femino, Andrea; Chin, Lynda; Greenberg, Roger A. (Cell Press, 1999-05-14)
    Maintenance of telomere length is predicted to be essential for bypass of senescence and crisis checkpoints in cancer cells. The impact of telomere dysfunction on tumorigenesis was assessed in successive generations of ...
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    p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis 

    DePinho, Ronald A.; Greider, Carol W.; Gottlieb, Geoffrey J.; Lee, Shwu-Luan; Tam, Alice; Shen, Qiong; Artandi, Steven E.; Chin, Lynda (Cell Press, 1999-05-14)
    Maintenance of telomere length and function is critical for the efficient proliferation of eukaryotic cells. Here, we examine the interactions between telomere dysfunction and p53 in cells and organs of telomerase-deficient ...

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    AuthorChin, Lynda (2)DePinho, Ronald A. (2)Gottlieb, Geoffrey J. (2)
    Greider, Carol W. (2)
    Artandi, Steven E. (1)Femino, Andrea (1)Greenberg, Roger A. (1)Lee, Kee-Ho (1)Lee, Shwu-Luan (1)Shen, Qiong (1)... View MoreSubjectNeoplasms/etiology (2)
    Telomere/physiology (2)
    Cyclin-Dependent Kinase Inhibitor p16/genetics (1)Telomerase/metabolism (1)Telomerase/physiology (1)Tumor Suppression Protein p53/physiology (1)... View MoreDate Issued
    1999 (2)
    Has File(s)Yes (2)

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