Now showing items 1-2 of 2
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
(Cell Press, 2001-10-05)
Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR/ G6 mice that have short telomeres with mice ...
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
(Cell Press, 1999-05-14)
Maintenance of telomere length is predicted to be essential for bypass of senescence and crisis checkpoints in cancer cells. The impact of telomere dysfunction on tumorigenesis was assessed in successive generations of ...