Now showing items 91-100 of 100
Concurrent expression of erythroid and renal aquaporin CHIP and appearance of water channel activity in perinatal rats
(American Society for Clinical Investigation, 1993-10)
Major phenotypic changes occur in red cell membranes during the perinatal period, but the underlying molecular explanations remain poorly defined. Aquaporin CHIP, the major erythroid and renal water channel, was studied ...
Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis
(American Society for Biochemistry and Molecular Biology, 1994-01-21)
CHIP is the archetypal member of the aquaporins, a widely expressed family of membrane water channels. The NH2- and COOH-terminal halves of CHIP are sequence-related, and hydropathy analysis predicted six membrane-spanning ...
Biochemistry of the erythrocyte Rh polypeptides: a review
(Yale School of Medicine, 1990-09)
The clinically important Rh blood group system is complex, consisting of multiple distinct antigens. Despite clinical recognition for over 50 years, the Rh blood group antigens have remained poorly understood on a molecular ...
Decreased membrane mechanical stability and in vivo loss of surface area reflect spectrin deficiencies in hereditary spherocytosis
(American Society for Clinical Investigation, 1988-08)
Whereas marked variations in the clinical manifestations of hereditary spherocytosis have long been recognized, we have only recently begun to define the molecular basis for this heterogeneity. An important unanswered ...
Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice
(National Academy of Sciences, 2006-09-05)
The aquaporin-4 (AQP4) pool in the perivascular astrocyte membranes has been shown to be critically involved in the formation and dissolution of brain edema. Cerebral edema is a major cause of morbidity and mortality in ...
Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution
(National Academy of Sciences, 2005-02-08)
Aquaporin (AQP) 6 belongs to the aquaporin water channel family. Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. Single-channel analyses have shown AQP6 to flicker rapidly ...
Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism
(National Academy of Sciences, 1994-12-20)
Cholangiocytes line the intrahepatic bile ducts and regulate salt and water secretion during bile formation, but the mechanism(s) regulating ductal water movement remains obscure. A water-selective channel, the aquaporin ...
Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia
(National Academy of Sciences, 1993-08-01)
The existence of water-selective channels has been postulated to explain the high water permeability of erythrocytes and certain epithelial cells. The aquaporin CHIP (channel-forming integral membrane protein of 28 kDa), ...
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
(National Academy of Sciences, 2001-02-27)
Aquaporin-1 (AQP1) water channel protein expression is increased by hypertonic stress. The contribution of changes in protein stability to hypertonic induction of AQP1 have not been described. Incubation of BALB/c fibroblasts ...
Aquaporin Water Channels: Nobel Lecture, December 8, 2003
(© The Nobel Foundation 2003, 2003-12-08)