Now showing items 21-31 of 31

    • Telomere dysfunction triggers developmentally regulated germ cell apoptosis 

      Greider, Carol W.; Chin, Lynda; DePinho, Ronald A.; Strong, Margaret A.; Rudolph, Karl Lenhard; Hemann, Michael T. (American Society for Cell Biology, 2001-07)
      Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper ...
    • Telomere Dysfunction Increases Mutation Rate and Genomic Instability 

      Greider, Carol W.; Feldser, David M.; Hackett, Jennifer A. (Cell Press, 2001-08-10)
      The increased tumor incidence in telomerase null mice suggests that telomere dysfunction induces genetic instability. To test this directly, we examined mutation rate in the absence of telomerase in S. cerevisiae. The ...
    • The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability 

      Greider, Carol W.; Hao, Ling-Yang; Strong, Margaret A.; Hemann, Michael T. (Cell Press, 2001-10-05)
      Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR􏰀/􏰀 G6 mice that have short telomeres with mice ...
    • A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA 

      Greider, Carol W.; Opperman, Kay Keyer; Chen, Jiunn-Liang (Oxford University Press, 2002-01-15)
      Telomerase is an enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The telomerase ribonucleoprotein complex consists of two essential components, a reverse transcriptase and ...
    • Short telomeres induce a DNA damage response in Saccharomyces cerevisiae 

      Greider, Carol W.; IJipma, Arne S. (American Society for Cell Biology, 2003-03)
      Telomerase-deficient Saccharomyces cerevisiae cells show a progressive decrease in telomere length. When grown for several days in log phase, the tlc1Delta cells initially display wild-type growth kinetics with subsequent ...
    • Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis 

      Armanios, Mary; Qi, Ling; Strong, Margaret A.; Karim, Baktiar O.; Greider, Carol W.; Huso, David L. (American Association of Cancer Research, 2003-12-01)
      To examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These mice exhibited increased germ cell death and chromosome fusions ...
    • Tracking Telomerase 

      Blackburn, Elizabeth H.; Greider, Carol W. (2004-01-23)
    • Phosphorylation of H2AX at short telomeres in T cells and fibroblasts 

      Greider, Carol W.; Strong, Margaret A.; Hao, Ling-Yang (American Society for Biochemistry and Molecular Biology, 2004-10-22)
      Eukaryotic cells undergo arrest and enter apoptosis in response to short telomeres. T cells from late generation mTR(-/-) mice that lack telomerase show increased apoptosis when stimulated to enter the cell cycle. The ...
    • Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity 

      Greider, Carol W.; Huso, David; Feldser, David M.; Karim, Baktiar; Strong, Margaret A.; Armanios, Mary; Hao, Ling-Yang (Cell Press, 2005-12-16)
      Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/ÿ mice on the CAST/EiJ background, which has short ...
    • Telomerase mutations in families with idiopathic pulmonary fibrosis 

      Loyd, James E.; Greider, Carol W.; Lansdorp, Peter M.; Phillips, John A., III; Vulto, Irma; Xie, Mingyi; Lawson, William E.; Markin, Cheryl; Ingersoll, Roxann G.; Alder, Jonathan K.; Cogan, Joy D.; Chen, Julian J.-L.; Armanios, Mary Y. (Massachusetts Medical Society, 2007-03-29)
      BACKGROUND: Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase ...
    • Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence 

      Greider, Carol W.; Feldser, David M. (Cell Press, 2007-05)
      Telomere maintenance is critical for cancer progression. To examine mechanisms of tumor suppression induced by short telomeres, we crossed mice deficient for the RNA component of telomerase, mTR(-/-), with Emu-myc transgenic ...