Now showing items 1-4 of 4

    • Functional characterization and developmental regulation of mouse telomerase RNA 

      Greider, Carol W.; Villeponteau, Bryant; Funk, Walter; Blasco, Maria A. (American Association for the Advancement of Science, 1995-09-01)
      Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the ...
    • The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence 

      Herr, Winship; Greider, Carol W.; Villeponteau, Bryant; Feng, Junli; Funk, Walter D.; Blasco, Maria A.; Hinckley, Craig S. (Oxford University Press, 1998-01-15)
      Telomerase is a ribonucleoprotein enzyme with an essential RNA component. Embedded within the telomerase RNA is a template sequence for telomere synthesis. We have characterized the structure of the 5' regions of the human ...
    • Secondary structure of vertebrate telomerase RNA 

      Greider, Carol W.; Blasco, Maria A.; Chen, Jiunn-Liang (Cell Press, 2000-03-03)
      Telomerase is a ribonucleoprotein enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The essential RNA component of telomerase provides the template for telomeric repeat ...
    • Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA 

      Greider, Carol W.; DePinho, Ronald A.; Lansdorp, Peter M.; Semper, Enrique; Hande, M. Prakash; Lee, Han-Woong; Blasco, Maria A. (Cell Press, 1997-10-03)
      To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six ...