Now showing items 1-5 of 5

    • Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice 

      DePinho, Ronald A.; Greider, Carol W.; Gottlieb, Geoffrey J.; Blasco, Maria; Lee, Han-Woong; Chang, Sandy; Rudolph, Karl Lenhard (Cell Press, 1999-03-05)
      Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the ...
    • p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis 

      DePinho, Ronald A.; Greider, Carol W.; Gottlieb, Geoffrey J.; Lee, Shwu-Luan; Tam, Alice; Shen, Qiong; Artandi, Steven E.; Chin, Lynda (Cell Press, 1999-05-14)
      Maintenance of telomere length and function is critical for the efficient proliferation of eukaryotic cells. Here, we examine the interactions between telomere dysfunction and p53 in cells and organs of telomerase-deficient ...
    • Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. 

      DePinho, Ronald A.; Greider, Carol W.; Singer, Robert H.; Gottlieb, Geoffrey J.; Lee, Kee-Ho; Femino, Andrea; Chin, Lynda; Greenberg, Roger A. (Cell Press, 1999-05-14)
      Maintenance of telomere length is predicted to be essential for bypass of senescence and crisis checkpoints in cancer cells. The impact of telomere dysfunction on tumorigenesis was assessed in successive generations of ...
    • Telomere dysfunction triggers developmentally regulated germ cell apoptosis 

      Greider, Carol W.; Chin, Lynda; DePinho, Ronald A.; Strong, Margaret A.; Rudolph, Karl Lenhard; Hemann, Michael T. (American Society for Cell Biology, 2001-07)
      Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper ...
    • Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA 

      Greider, Carol W.; DePinho, Ronald A.; Lansdorp, Peter M.; Semper, Enrique; Hande, M. Prakash; Lee, Han-Woong; Blasco, Maria A. (Cell Press, 1997-10-03)
      To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six ...