Now showing items 1-2 of 2

    • Telomerase mutations in families with idiopathic pulmonary fibrosis 

      Loyd, James E.; Greider, Carol W.; Lansdorp, Peter M.; Phillips, John A., III; Vulto, Irma; Xie, Mingyi; Lawson, William E.; Markin, Cheryl; Ingersoll, Roxann G.; Alder, Jonathan K.; Cogan, Joy D.; Chen, Julian J.-L.; Armanios, Mary Y. (Massachusetts Medical Society, 2007-03-29)
      BACKGROUND: Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase ...
    • Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA 

      Greider, Carol W.; DePinho, Ronald A.; Lansdorp, Peter M.; Semper, Enrique; Hande, M. Prakash; Lee, Han-Woong; Blasco, Maria A. (Cell Press, 1997-10-03)
      To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six ...