Now showing items 1-5 of 5

    • A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA 

      Greider, Carol W.; Opperman, Kay Keyer; Chen, Jiunn-Liang (Oxford University Press, 2002-01-15)
      Telomerase is an enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The telomerase ribonucleoprotein complex consists of two essential components, a reverse transcriptase and ...
    • Functional characterization and developmental regulation of mouse telomerase RNA 

      Greider, Carol W.; Villeponteau, Bryant; Funk, Walter; Blasco, Maria A. (American Association for the Advancement of Science, 1995-09-01)
      Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the ...
    • Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues 

      Shay, Jerry W.; Avilion, Ariel A.; Piatyszek, Mieczyslaw A.; Gupta, Jyothi; Greider, Carol W.; Bacchetti, Silvia (American Association of Cancer Research, 1996-02-01)
      Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and from many tumor adjacent tissue samples. With the recently cloned ...
    • Identification of two RNA-binding proteins associated with human telomerase RNA 

      Greider, Carol W.; Sternglanz, Rolf; Le, Siyuan (American Society for Cell Biology, 2000-03)
      Telomerase plays a crucial role in telomere maintenance in vivo. To understand telomerase regulation, we have been characterizing components of the enzyme. To date several components of the mammalian telomerase holoenzyme ...
    • The RNA component of human telomerase 

      Greider, Carol W.; Feng, Junli (American Association for the Advancement of Science, 1995-09-01)
      Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the ends from damage and rearrangements. Telomere repeats are synthesized by telomerase, a ribonucleic acid (RNA)-protein complex. Here, the ...