Now showing items 1-5 of 5

    • Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro 

      Greider, Carol W.; Autexier, Chantal (Oxford University Press, 1998-02-01)
      Telomere-specific repeat sequences are essential for chromosome end stability. Telomerase maintains telomere length by adding sequences de novo onto chromosome ends. The template domain of the telomerase RNA component ...
    • Secondary structure of vertebrate telomerase RNA 

      Greider, Carol W.; Blasco, Maria A.; Chen, Jiunn-Liang (Cell Press, 2000-03-03)
      Telomerase is a ribonucleoprotein enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The essential RNA component of telomerase provides the template for telomeric repeat ...
    • Short telomeres induce a DNA damage response in Saccharomyces cerevisiae 

      Greider, Carol W.; IJipma, Arne S. (American Society for Cell Biology, 2003-03)
      Telomerase-deficient Saccharomyces cerevisiae cells show a progressive decrease in telomere length. When grown for several days in log phase, the tlc1Delta cells initially display wild-type growth kinetics with subsequent ...
    • Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity 

      Greider, Carol W.; Huso, David; Feldser, David M.; Karim, Baktiar; Strong, Margaret A.; Armanios, Mary; Hao, Ling-Yang (Cell Press, 2005-12-16)
      Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/ÿ mice on the CAST/EiJ background, which has short ...
    • Telomerase mutations in families with idiopathic pulmonary fibrosis 

      Loyd, James E.; Greider, Carol W.; Lansdorp, Peter M.; Phillips, John A., III; Vulto, Irma; Xie, Mingyi; Lawson, William E.; Markin, Cheryl; Ingersoll, Roxann G.; Alder, Jonathan K.; Cogan, Joy D.; Chen, Julian J.-L.; Armanios, Mary Y. (Massachusetts Medical Society, 2007-03-29)
      BACKGROUND: Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase ...