Now showing items 1-9 of 9

    • A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA 

      Greider, Carol W.; Opperman, Kay Keyer; Chen, Jiunn-Liang (Oxford University Press, 2002-01-15)
      Telomerase is an enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The telomerase ribonucleoprotein complex consists of two essential components, a reverse transcriptase and ...
    • Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues 

      Shay, Jerry W.; Avilion, Ariel A.; Piatyszek, Mieczyslaw A.; Gupta, Jyothi; Greider, Carol W.; Bacchetti, Silvia (American Association of Cancer Research, 1996-02-01)
      Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and from many tumor adjacent tissue samples. With the recently cloned ...
    • Identification of two RNA-binding proteins associated with human telomerase RNA 

      Greider, Carol W.; Sternglanz, Rolf; Le, Siyuan (American Society for Cell Biology, 2000-03)
      Telomerase plays a crucial role in telomere maintenance in vivo. To understand telomerase regulation, we have been characterizing components of the enzyme. To date several components of the mammalian telomerase holoenzyme ...
    • Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro 

      Greider, Carol W.; Autexier, Chantal (Oxford University Press, 1998-02-01)
      Telomere-specific repeat sequences are essential for chromosome end stability. Telomerase maintains telomere length by adding sequences de novo onto chromosome ends. The template domain of the telomerase RNA component ...
    • Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. 

      DePinho, Ronald A.; Greider, Carol W.; Singer, Robert H.; Gottlieb, Geoffrey J.; Lee, Kee-Ho; Femino, Andrea; Chin, Lynda; Greenberg, Roger A. (Cell Press, 1999-05-14)
      Maintenance of telomere length is predicted to be essential for bypass of senescence and crisis checkpoints in cancer cells. The impact of telomere dysfunction on tumorigenesis was assessed in successive generations of ...
    • Short telomeres induce a DNA damage response in Saccharomyces cerevisiae 

      Greider, Carol W.; IJipma, Arne S. (American Society for Cell Biology, 2003-03)
      Telomerase-deficient Saccharomyces cerevisiae cells show a progressive decrease in telomere length. When grown for several days in log phase, the tlc1Delta cells initially display wild-type growth kinetics with subsequent ...
    • The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability 

      Greider, Carol W.; Hao, Ling-Yang; Strong, Margaret A.; Hemann, Michael T. (Cell Press, 2001-10-05)
      Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR􏰀/􏰀 G6 mice that have short telomeres with mice ...
    • Telomerase mutations in families with idiopathic pulmonary fibrosis 

      Loyd, James E.; Greider, Carol W.; Lansdorp, Peter M.; Phillips, John A., III; Vulto, Irma; Xie, Mingyi; Lawson, William E.; Markin, Cheryl; Ingersoll, Roxann G.; Alder, Jonathan K.; Cogan, Joy D.; Chen, Julian J.-L.; Armanios, Mary Y. (Massachusetts Medical Society, 2007-03-29)
      BACKGROUND: Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase ...
    • Tracking Telomerase 

      Blackburn, Elizabeth H.; Greider, Carol W. (2004-01-23)