Now showing items 1-4 of 4
Secondary structure of vertebrate telomerase RNA
(Cell Press, 2000-03-03)
Telomerase is a ribonucleoprotein enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The essential RNA component of telomerase provides the template for telomeric repeat ...
Functional characterization and developmental regulation of mouse telomerase RNA
(American Association for the Advancement of Science, 1995-09-01)
Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the ...
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
(Cell Press, 1997-10-03)
To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six ...
The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence
(Oxford University Press, 1998-01-15)
Telomerase is a ribonucleoprotein enzyme with an essential RNA component. Embedded within the telomerase RNA is a template sequence for telomere synthesis. We have characterized the structure of the 5' regions of the human ...