Now showing items 1-3 of 3
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
(Cell Press, 2001-08-10)
The increased tumor incidence in telomerase null mice suggests that telomere dysfunction induces genetic instability. To test this directly, we examined mutation rate in the absence of telomerase in S. cerevisiae. The ...
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
(Cell Press, 2005-12-16)
Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/ÿ mice on the CAST/EiJ background, which has short ...
Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence
(Cell Press, 2007-05)
Telomere maintenance is critical for cancer progression. To examine mechanisms of tumor suppression induced by short telomeres, we crossed mice deficient for the RNA component of telomerase, mTR(-/-), with Emu-myc transgenic ...