Now showing items 1-4 of 4
Telomere dysfunction triggers developmentally regulated germ cell apoptosis
(American Society for Cell Biology, 2001-07)
Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper ...
G-strand overhangs on telomeres in telomerase-deficient mouse cells
(Oxford University Press, 1999-10-15)
Telomeres of eukaryotic chromosomes contain 3' overhangs which are thought to be essential for the maintenance of proper chromosome end structure and function. We examined the requirement for telomerase activity for the ...
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
(Cell Press, 2001-10-05)
Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR/ G6 mice that have short telomeres with mice ...
Wild-derived inbred mouse strains have short telomeres
(Oxford University Press, 2000-11-15)
Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions ...