Now showing items 1-10 of 14
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis
(American Association of Cancer Research, 2003-12-01)
To examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These mice exhibited increased germ cell death and chromosome fusions ...
Phosphorylation of H2AX at short telomeres in T cells and fibroblasts
(American Society for Biochemistry and Molecular Biology, 2004-10-22)
Eukaryotic cells undergo arrest and enter apoptosis in response to short telomeres. T cells from late generation mTR(-/-) mice that lack telomerase show increased apoptosis when stimulated to enter the cell cycle. The ...
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
(Cell Press, 2001-10-05)
Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR/ G6 mice that have short telomeres with mice ...
Telomere dysfunction triggers developmentally regulated germ cell apoptosis
(American Society for Cell Biology, 2001-07)
Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper ...
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
(Cell Press, 2005-12-16)
Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/ÿ mice on the CAST/EiJ background, which has short ...
Wild-derived inbred mouse strains have short telomeres
(Oxford University Press, 2000-11-15)
Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions ...
A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA
(Oxford University Press, 2002-01-15)
Telomerase is an enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The telomerase ribonucleoprotein complex consists of two essential components, a reverse transcriptase and ...
Identification of two RNA-binding proteins associated with human telomerase RNA
(American Society for Cell Biology, 2000-03)
Telomerase plays a crucial role in telomere maintenance in vivo. To understand telomerase regulation, we have been characterizing components of the enzyme. To date several components of the mammalian telomerase holoenzyme ...
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
(Cell Press, 2001-08-10)
The increased tumor incidence in telomerase null mice suggests that telomere dysfunction induces genetic instability. To test this directly, we examined mutation rate in the absence of telomerase in S. cerevisiae. The ...