Now showing items 1-4 of 4
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis
(American Association of Cancer Research, 2003-12-01)
To examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These mice exhibited increased germ cell death and chromosome fusions ...
Telomerase mutations in families with idiopathic pulmonary fibrosis
(Massachusetts Medical Society, 2007-03-29)
BACKGROUND: Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase ...
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
(Cell Press, 2001-08-10)
The increased tumor incidence in telomerase null mice suggests that telomere dysfunction induces genetic instability. To test this directly, we examined mutation rate in the absence of telomerase in S. cerevisiae. The ...
Wild-derived inbred mouse strains have short telomeres
(Oxford University Press, 2000-11-15)
Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions ...