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dc.contributor.authorShay, Jerry W.
dc.contributor.authorAvilion, Ariel A.
dc.contributor.authorPiatyszek, Mieczyslaw A.
dc.contributor.authorGupta, Jyothi
dc.contributor.authorGreider, Carol W.
dc.contributor.authorBacchetti, Silvia
dc.date.accessioned2009-11-05T16:38:15Z
dc.date.available2009-11-05T16:38:15Z
dc.date.issued1996-02-01
dc.identifier.citationAvilion, AA, et al. "Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues" Cancer Research 56, 645-650. February 1, 1996en_US
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/33534
dc.description.abstractTelomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and from many tumor adjacent tissue samples. With the recently cloned human telomerase RNA (hTR), we used Northern analysis to follow the levels of hTR in primary, precrisis, and immortalized cells. It was surprising that the amount of hTR was high in cell strains that lacked telomerase activity, and the levels did not parallel the increases in telomerase activity, which accompanies immortalization. In addition, although the hTR levels were somewhat higher in tumor samples compared to nontumor tissues, the level of hTR in a variety of different human tumors did not predict the level of telomerase activity in the tumor. Thus, whereas hTR was detected in all samples that have telomerase activity, the presence of the RNA was not a good predictor of the presence or amount of telomerase activity.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Association of Cancer Researchen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectNeoplasms/metabolismen_US
dc.subjectNeoplasms/enzymologyen_US
dc.subjectRNA/metabolismen_US
dc.subjectTelomerase/metabolismen_US
dc.titleHuman telomerase RNA and telomerase activity in immortal cell lines and tumor tissuesen_US
dc.typeArticleen_US


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