Short telomeres induce a DNA damage response in Saccharomyces cerevisiae

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Title: Short telomeres induce a DNA damage response in Saccharomyces cerevisiae
Author: Greider, Carol W.; IJipma, Arne S.
Abstract: Telomerase-deficient Saccharomyces cerevisiae cells show a progressive decrease in telomere length. When grown for several days in log phase, the tlc1Delta cells initially display wild-type growth kinetics with subsequent loss of growth potential after which survivors are generated via RAD52-dependent homologous recombination. We found that chromosome loss in these telomerase-deficient cells only increased after a significant decline in growth potential of the culture. At earlier stages of growth, as the telomerase-deficient cells began to show loss of growth potential, the cells arrested in G2/M and showed RNR3 induction and Rad53p phosphorylation. These responses were dependent on RAD24 and MEC1, suggesting that short telomeres are recognized as DNA damage and signal G2/M arrest.
URI: http://jhir.library.jhu.edu/handle/1774.2/33539
Date: 2003-03
Citation: IJipma, Arne S. and Carol W. Greider. "Short telomeres induce a DNA damage response in Saccharomyces cerevisiae" Molecular Biology of the Cell 14 (987-1001) (2003 March). Article originally published: http://www.molbiolcell.org/cgi/content/full/14/3/987
Subject: Telomere/metabolism
Telomerase/metabolism
Telomerase/genetics
DNA Damage
Cell Cycle Proteins/metabolism
Cell Cycle/physiology

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