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dc.contributor.authorGreider, Carol W.
dc.contributor.authorIJipma, Arne S.
dc.date.accessioned2009-11-05T18:46:31Z
dc.date.available2009-11-05T18:46:31Z
dc.date.issued2003-03
dc.identifier.citationIJipma, Arne S. and Carol W. Greider. "Short telomeres induce a DNA damage response in Saccharomyces cerevisiae" Molecular Biology of the Cell 14 (987-1001) (2003 March). Article originally published: http://www.molbiolcell.org/cgi/content/full/14/3/987en
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/33539
dc.description.abstractTelomerase-deficient Saccharomyces cerevisiae cells show a progressive decrease in telomere length. When grown for several days in log phase, the tlc1Delta cells initially display wild-type growth kinetics with subsequent loss of growth potential after which survivors are generated via RAD52-dependent homologous recombination. We found that chromosome loss in these telomerase-deficient cells only increased after a significant decline in growth potential of the culture. At earlier stages of growth, as the telomerase-deficient cells began to show loss of growth potential, the cells arrested in G2/M and showed RNR3 induction and Rad53p phosphorylation. These responses were dependent on RAD24 and MEC1, suggesting that short telomeres are recognized as DNA damage and signal G2/M arrest.en
dc.language.isoen_USen
dc.publisherAmerican Society for Cell Biologyen
dc.subjectTelomere/metabolismen
dc.subjectTelomerase/metabolismen
dc.subjectTelomerase/geneticsen
dc.subjectDNA Damageen
dc.subjectCell Cycle Proteins/metabolismen
dc.subjectCell Cycle/physiologyen
dc.titleShort telomeres induce a DNA damage response in Saccharomyces cerevisiaeen
dc.typeArticleen


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