Short telomeres induce a DNA damage response in Saccharomyces cerevisiae

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dc.contributor.author Greider, Carol W.
dc.contributor.author IJipma, Arne S.
dc.date.accessioned 2009-11-05T18:46:31Z
dc.date.available 2009-11-05T18:46:31Z
dc.date.issued 2003-03
dc.identifier.citation IJipma, Arne S. and Carol W. Greider. "Short telomeres induce a DNA damage response in Saccharomyces cerevisiae" Molecular Biology of the Cell 14 (987-1001) (2003 March). Article originally published: http://www.molbiolcell.org/cgi/content/full/14/3/987 en
dc.identifier.uri http://jhir.library.jhu.edu/handle/1774.2/33539
dc.description.abstract Telomerase-deficient Saccharomyces cerevisiae cells show a progressive decrease in telomere length. When grown for several days in log phase, the tlc1Delta cells initially display wild-type growth kinetics with subsequent loss of growth potential after which survivors are generated via RAD52-dependent homologous recombination. We found that chromosome loss in these telomerase-deficient cells only increased after a significant decline in growth potential of the culture. At earlier stages of growth, as the telomerase-deficient cells began to show loss of growth potential, the cells arrested in G2/M and showed RNR3 induction and Rad53p phosphorylation. These responses were dependent on RAD24 and MEC1, suggesting that short telomeres are recognized as DNA damage and signal G2/M arrest. en
dc.description.provenance Submitted by David Reynolds (davidr@jhu.edu) on 2009-11-05T18:46:31Z No. of bitstreams: 1 MoleBiolCell14.pdf: 768360 bytes, checksum: d765cdad015abf676f05e0ae575ad642 (MD5) en
dc.description.provenance Made available in DSpace on 2009-11-05T18:46:31Z (GMT). No. of bitstreams: 1 MoleBiolCell14.pdf: 768360 bytes, checksum: d765cdad015abf676f05e0ae575ad642 (MD5) Previous issue date: 2003-03 en
dc.language.iso en_US en
dc.publisher American Society for Cell Biology en
dc.subject Telomere/metabolism en
dc.subject Telomerase/metabolism en
dc.subject Telomerase/genetics en
dc.subject DNA Damage en
dc.subject Cell Cycle Proteins/metabolism en
dc.subject Cell Cycle/physiology en
dc.title Short telomeres induce a DNA damage response in Saccharomyces cerevisiae en
dc.type Article en

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