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dc.contributor.authorHerr, Winship
dc.contributor.authorGreider, Carol W.
dc.contributor.authorVilleponteau, Bryant
dc.contributor.authorFeng, Junli
dc.contributor.authorFunk, Walter D.
dc.contributor.authorBlasco, Maria A.
dc.contributor.authorHinckley, Craig S.
dc.date.accessioned2009-11-05T22:09:03Z
dc.date.available2009-11-05T22:09:03Z
dc.date.issued1998-01-15
dc.identifier.citationHinckley, Craig S. et al. "The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence" 26 (2) (1998 January 15): 532-536. Originally published: http://nar.oxfordjournals.org/cgi/content/full/26/2/532en
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/33543
dc.description.abstractTelomerase is a ribonucleoprotein enzyme with an essential RNA component. Embedded within the telomerase RNA is a template sequence for telomere synthesis. We have characterized the structure of the 5' regions of the human and mouse telomerase-RNA genes, and have found a striking difference in the location of the template sequence: Whereas the 5'-end of the human telomerase RNA lies 45 nt from the telomerase-RNA template sequence, the 5'-end of the mouse telomerase RNA lies just 2 nt from the telomerase-RNA template sequence. Analysis of genomic sequences flanking the 5'-end of the human and mouse telomerase RNA-coding sequences reveals similar promoter-element arrangements typical of mRNA-type promoters: a TATA box-like element and an upstream region containing a consensus CCAAT box. This putative promoter structure contrasts with that of the ciliate telomerase-RNA genes whose structure resembles RNA polymerase III U6 small nuclear RNA (snRNA) promoters. These and other comparisons suggest that, during evolution, both the RNA-polymerase specificity of telomerase RNA-gene promoters and, more recently, the position of the template sequence in the telomerase RNA changed.en
dc.language.isoen_USen
dc.publisherOxford University Pressen
dc.subjectRNA/chemistryen
dc.subjectSequence Alignmenten
dc.subjectTelomerase/chemistryen
dc.subjectConsensus Sequenceen
dc.subjectBase Sequenceen
dc.titleThe mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequenceen
dc.typeArticleen


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