The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence

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dc.contributor.author Herr, Winship
dc.contributor.author Greider, Carol W.
dc.contributor.author Villeponteau, Bryant
dc.contributor.author Feng, Junli
dc.contributor.author Funk, Walter D.
dc.contributor.author Blasco, Maria A.
dc.contributor.author Hinckley, Craig S.
dc.date.accessioned 2009-11-05T22:09:03Z
dc.date.available 2009-11-05T22:09:03Z
dc.date.issued 1998-01-15
dc.identifier.citation Hinckley, Craig S. et al. "The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence" 26 (2) (1998 January 15): 532-536. Originally published: http://nar.oxfordjournals.org/cgi/content/full/26/2/532 en
dc.identifier.uri http://jhir.library.jhu.edu/handle/1774.2/33543
dc.description.abstract Telomerase is a ribonucleoprotein enzyme with an essential RNA component. Embedded within the telomerase RNA is a template sequence for telomere synthesis. We have characterized the structure of the 5' regions of the human and mouse telomerase-RNA genes, and have found a striking difference in the location of the template sequence: Whereas the 5'-end of the human telomerase RNA lies 45 nt from the telomerase-RNA template sequence, the 5'-end of the mouse telomerase RNA lies just 2 nt from the telomerase-RNA template sequence. Analysis of genomic sequences flanking the 5'-end of the human and mouse telomerase RNA-coding sequences reveals similar promoter-element arrangements typical of mRNA-type promoters: a TATA box-like element and an upstream region containing a consensus CCAAT box. This putative promoter structure contrasts with that of the ciliate telomerase-RNA genes whose structure resembles RNA polymerase III U6 small nuclear RNA (snRNA) promoters. These and other comparisons suggest that, during evolution, both the RNA-polymerase specificity of telomerase RNA-gene promoters and, more recently, the position of the template sequence in the telomerase RNA changed. en
dc.description.provenance Submitted by David Reynolds (davidr@jhu.edu) on 2009-11-05T22:09:03Z No. of bitstreams: 1 NucAcidRes1998-2.pdf: 133860 bytes, checksum: c784ace7ce84f7004e5cd5ff5f2ca6ea (MD5) en
dc.description.provenance Made available in DSpace on 2009-11-05T22:09:03Z (GMT). No. of bitstreams: 1 NucAcidRes1998-2.pdf: 133860 bytes, checksum: c784ace7ce84f7004e5cd5ff5f2ca6ea (MD5) Previous issue date: 1998-01-15 en
dc.language.iso en_US en
dc.publisher Oxford University Press en
dc.subject RNA/chemistry en
dc.subject Sequence Alignment en
dc.subject Telomerase/chemistry en
dc.subject Consensus Sequence en
dc.subject Base Sequence en
dc.title The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence en
dc.type Article en

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