Wild-derived inbred mouse strains have short telomeres

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Title: Wild-derived inbred mouse strains have short telomeres
Author: Greider, Carol W.; Hemann, Michael T.
Abstract: Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strains than in the established strains. We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.
URI: http://jhir.library.jhu.edu/handle/1774.2/33545
Date: 2000-11-15
Citation: Hemann, Michael T. and Carol W. Greider. "Wild-derived inbred mouse strains have short telomeres" Nucleic Acids Research 28 (22) (2000 November 15): 4474-4478. Originally published: http://nar.oxfordjournals.org/cgi/reprint/28/22/4474
Subject: Telomere/genetics
In Situ Hybridization, Fluorescence
Electrophoresis, Gel, Pulse-Field
DNA/genetics

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