Functional characterization and developmental regulation of mouse telomerase RNA

Show full item record

Title: Functional characterization and developmental regulation of mouse telomerase RNA
Author: Greider, Carol W.; Villeponteau, Bryant; Funk, Walter; Blasco, Maria A.
Abstract: Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the template region in vivo generated altered telomerase products. The shorter template regions of the mouse and other rodent telomerase RNAs could account for the shorter distribution of products (processivity) generated by the mouse enzyme relative to the human telomerase. Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts. RNA was detected in all newborn mouse tissues tested but was decreased during postnatal development.
URI: http://jhir.library.jhu.edu/handle/1774.2/33547
Date: 1995-09-01
Citation: Blasco, Maria A. et al. "Functional characterization and developmental regulation of mouse telomerase RNA" Science 269 (5228) (1995 September 1): 1267-1270. Originally published: DOI: 10.1126/science.7544492
Subject: RNA/metabolism
Gene Expression Regulation, Developmental
DNA Nucleotidylexotransferase /metabolism

Files in this item

Files Size Format Download
Science269.pdf 1.354Mb application/pdf Download

The following license files are associated with this item:

This item appears in the following Collection(s)

Show full item record