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dc.contributor.authorGreider, Carol W.
dc.contributor.authorVilleponteau, Bryant
dc.contributor.authorFunk, Walter
dc.contributor.authorBlasco, Maria A.
dc.date.accessioned2009-11-06T15:59:34Z
dc.date.available2009-11-06T15:59:34Z
dc.date.issued1995-09-01
dc.identifier.citationBlasco, Maria A. et al. "Functional characterization and developmental regulation of mouse telomerase RNA" Science 269 (5228) (1995 September 1): 1267-1270. Originally published: DOI: 10.1126/science.7544492en_US
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/33547
dc.description.abstractTelomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the template region in vivo generated altered telomerase products. The shorter template regions of the mouse and other rodent telomerase RNAs could account for the shorter distribution of products (processivity) generated by the mouse enzyme relative to the human telomerase. Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts. RNA was detected in all newborn mouse tissues tested but was decreased during postnatal development.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.subjectRNA/metabolismen_US
dc.subjectGene Expression Regulation, Developmentalen_US
dc.subjectDNA Nucleotidylexotransferase /metabolismen_US
dc.titleFunctional characterization and developmental regulation of mouse telomerase RNAen_US
dc.typeArticleen_US


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