The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

Show full item record

Title: The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
Author: Greider, Carol W.; Hao, Ling-Yang; Strong, Margaret A.; Hemann, Michael T.
Abstract: Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR􏰀/􏰀 G6 mice that have short telomeres with mice heterozygous for telomerase (mTR􏰁/􏰀) that have long telomeres. The phenotype of the telomerase null offspring was similar to that of the late generation parent, although only half of the chromosomes were short. Strikingly, spectral karyotyping (SKY) analysis revealed that loss of telomere function occurred pref- erentially on chromosomes with critically short telo- meres. Our data indicate that, while average telomere length is measured in most studies, it is not the aver- age but rather the shortest telomeres that constitute telomere dysfunction and limit cellular survival in the absence of telomerase.
URI: http://jhir.library.jhu.edu/handle/1774.2/33666
Date: 2001-10-05
Citation: Reprinted from Cell 107 (1). Hemann Michael T., et al. "The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability", pg. 67-77, copyright 2001, with permission from Elsevier. Original version available at http://www.cell.com
Subject: Telomere/physiology
Telomerase/metabolism
Chromosomes/physiology
Cell Survival

Files in this item

Files Size Format Download
Cell2001.pdf 481.6Kb application/pdf Download

The following license files are associated with this item:

This item appears in the following Collection(s)

Show full item record