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dc.contributor.authorGreider, Carol W.
dc.contributor.authorHao, Ling-Yang
dc.contributor.authorStrong, Margaret A.
dc.contributor.authorHemann, Michael T.
dc.date.accessioned2009-11-28T15:55:54Z
dc.date.available2009-11-28T15:55:54Z
dc.date.issued2001-10-05
dc.identifier.citationReprinted from Cell 107 (1). Hemann Michael T., et al. "The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability", pg. 67-77, copyright 2001, with permission from Elsevier. Original version available at http://www.cell.comen_US
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/33666
dc.description.abstractLoss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR􏰀/􏰀 G6 mice that have short telomeres with mice heterozygous for telomerase (mTR􏰁/􏰀) that have long telomeres. The phenotype of the telomerase null offspring was similar to that of the late generation parent, although only half of the chromosomes were short. Strikingly, spectral karyotyping (SKY) analysis revealed that loss of telomere function occurred pref- erentially on chromosomes with critically short telo- meres. Our data indicate that, while average telomere length is measured in most studies, it is not the aver- age but rather the shortest telomeres that constitute telomere dysfunction and limit cellular survival in the absence of telomerase.en_US
dc.language.isoen_USen_US
dc.publisherCell Pressen_US
dc.subjectTelomere/physiologyen_US
dc.subjectTelomerase/metabolismen_US
dc.subjectChromosomes/physiologyen_US
dc.subjectCell Survivalen_US
dc.titleThe Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stabilityen_US
dc.typeArticleen_US


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