The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

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dc.contributor.author Greider, Carol W.
dc.contributor.author Hao, Ling-Yang
dc.contributor.author Strong, Margaret A.
dc.contributor.author Hemann, Michael T.
dc.date.accessioned 2009-11-28T15:55:54Z
dc.date.available 2009-11-28T15:55:54Z
dc.date.issued 2001-10-05
dc.identifier.citation Reprinted from Cell 107 (1). Hemann Michael T., et al. "The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability", pg. 67-77, copyright 2001, with permission from Elsevier. Original version available at http://www.cell.com en
dc.identifier.uri http://jhir.library.jhu.edu/handle/1774.2/33666
dc.description.abstract Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trig- ger cellular responses to telomere dysfunction, we crossed mTR􏰀/􏰀 G6 mice that have short telomeres with mice heterozygous for telomerase (mTR􏰁/􏰀) that have long telomeres. The phenotype of the telomerase null offspring was similar to that of the late generation parent, although only half of the chromosomes were short. Strikingly, spectral karyotyping (SKY) analysis revealed that loss of telomere function occurred pref- erentially on chromosomes with critically short telo- meres. Our data indicate that, while average telomere length is measured in most studies, it is not the aver- age but rather the shortest telomeres that constitute telomere dysfunction and limit cellular survival in the absence of telomerase. en
dc.description.provenance Submitted by David Reynolds (davidr@jhu.edu) on 2009-11-28T15:55:54Z No. of bitstreams: 1 Cell2001.pdf: 481651 bytes, checksum: 030c8a407ae27c9273ff20b5225b0a93 (MD5) en
dc.description.provenance Made available in DSpace on 2009-11-28T15:55:54Z (GMT). No. of bitstreams: 1 Cell2001.pdf: 481651 bytes, checksum: 030c8a407ae27c9273ff20b5225b0a93 (MD5) Previous issue date: 2001-10-05 en
dc.language.iso en_US en
dc.publisher Cell Press en
dc.subject Telomere/physiology en
dc.subject Telomerase/metabolism en
dc.subject Chromosomes/physiology en
dc.subject Cell Survival en
dc.title The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability en
dc.type Article en

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