Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence

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dc.contributor.author Greider, Carol W.
dc.contributor.author Feldser, David M.
dc.date.accessioned 2009-11-30T19:22:10Z
dc.date.available 2009-11-30T19:22:10Z
dc.date.issued 2007-05
dc.identifier.citation Reprinted from Cancer Cell 11, Feldser, David M. and Carol W. Greider, "Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence", pg. 461-469, copyright 2001 with permission from Elsevier. Original version available at http://www.cell.com en
dc.identifier.uri http://jhir.library.jhu.edu/handle/1774.2/33685
dc.description.abstract Telomere maintenance is critical for cancer progression. To examine mechanisms of tumor suppression induced by short telomeres, we crossed mice deficient for the RNA component of telomerase, mTR(-/-), with Emu-myc transgenic mice, an established model of Burkitt's lymphoma. Short telomeres suppressed tumor formation in Emu-myc transgenic animals. Expression of Bcl2 blocked apoptosis in tumor cells, but surprisingly, mice with short telomeres were still resistant to tumor formation. Staining for markers of cellular senescence showed that pretumor cells induced senescence in response to short telomeres. Loss of p53 abrogated the short telomere response. This study provides in vivo evidence for the existence of a p53-mediated senescence mechanism in response to short telomeres that suppresses tumorigenesis. en
dc.description.provenance Submitted by David Reynolds (davidr@jhu.edu) on 2009-11-30T19:22:10Z No. of bitstreams: 1 CancerCell.pdf: 1108617 bytes, checksum: 52498e95530cac17d017c9e8a43b42b1 (MD5) en
dc.description.provenance Made available in DSpace on 2009-11-30T19:22:10Z (GMT). No. of bitstreams: 1 CancerCell.pdf: 1108617 bytes, checksum: 52498e95530cac17d017c9e8a43b42b1 (MD5) Previous issue date: 2007-05 en
dc.language.iso en_US en
dc.publisher Cell Press en
dc.subject Telomere en
dc.subject Cell Aging/genetics en
dc.subject Burkitt Lymphoma/genetics en
dc.title Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence en
dc.type Article en

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