Biochemistry of the erythrocyte Rh polypeptides: a review

Show simple item record

dc.contributor.author Hartel-Schenk, S
dc.contributor.author Smith, B L
dc.contributor.author Agre, P
dc.date.accessioned 2010-02-17T20:58:52Z
dc.date.available 2010-02-17T20:58:52Z
dc.date.issued 1990-09
dc.identifier.citation Yale J Biol Med. 1990 Sep–Oct; 63(5): 461–467 en
dc.identifier.uri http://jhir.library.jhu.edu/handle/1774.2/33801
dc.description.abstract The clinically important Rh blood group system is complex, consisting of multiple distinct antigens. Despite clinical recognition for over 50 years, the Rh blood group antigens have remained poorly understood on a molecular level until the recent identification and characterization of the "Rh polypeptides," the core structural proteins of the Rh antigens. This group of erythrocyte membrane proteins of molecular weight 30,000-35,000 daltons was first recognized by employing Rh-specific antibodies to immunoprecipitate radiolabeled components of erythrocyte membranes. By using antibodies specific for the Rh D, c, and E antigens, a series of highly related non-identical proteins were immunoprecipitated, indicating that the Rh antigens are composed of multiple related proteins. The Rh polypeptides have been purified and characterized, and they were found to have several unusual biochemical characteristics. The Rh polypeptides penetrate the membrane bilayer; they are linked to the underlying membrane skeleton; they are covalently fatty acid acylated with palmitate. While the Rh antigenic reactivity is unique to human erythrocytes, the Rh polypeptides have been isolated from erythrocytes of diverse species and are thought to be fundamental components of all mammalian erythrocyte membranes. The functional role of the Rh polypeptides remains undefined, but a role in the organization of membrane phospholipid is suspected. en
dc.description.provenance Submitted by Janice Chen (janice.chen@jhu.edu) on 2010-02-04T16:20:24Z No. of bitstreams: 1 yjbm00065-0118.pdf: 895856 bytes, checksum: ee0b6476aedd597f2d7870404f88c3d0 (MD5) en
dc.description.provenance Approved for entry into archive by David Reynolds(davidr@jhu.edu) on 2010-02-17T20:58:52Z (GMT) No. of bitstreams: 1 yjbm00065-0118.pdf: 895856 bytes, checksum: ee0b6476aedd597f2d7870404f88c3d0 (MD5) en
dc.description.provenance Made available in DSpace on 2010-02-17T20:58:52Z (GMT). No. of bitstreams: 1 yjbm00065-0118.pdf: 895856 bytes, checksum: ee0b6476aedd597f2d7870404f88c3d0 (MD5) Previous issue date: 1990-09 en
dc.language.iso en_US en
dc.publisher Yale School of Medicine en
dc.subject Rh-Hr Blood-Group System/physiology en
dc.subject Peptides/chemistry en
dc.subject Erythrocytes/chemistry en
dc.title Biochemistry of the erythrocyte Rh polypeptides: a review en
dc.type Article en

Files in this item

Files Size Format Download
yjbm00065-0118.pdf 895.8Kb application/pdf Download

This item appears in the following Collection(s)

Show simple item record