Show simple item record

dc.contributor.authorAgre, Peter
dc.contributor.authorNielsen, Søren
dc.contributor.authorKing, Landon S.
dc.date.accessioned2010-05-13T18:55:13Z
dc.date.available2010-05-13T18:55:13Z
dc.date.issued1997-11
dc.identifier.citationAmerican Journal of Physiology, 1997 Nov;273(5 Pt 1):C1541-8. http://ajpcell.physiology.org/cgi/content/full/273/5/C1541en_US
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/34115
dc.description.abstractDevelopmental expression of aquaporin water transport proteins is not well understood in respiratory tract or secretory glands; here we define aquaporin protein ontogeny in rat. Expression of aquaporin-3 (AQP3), AQP4, and AQP5 proteins occurs within 2 wk after birth, whereas AQP1 first appears before birth. In most tissues, aquaporin protein expression increases progressively, although transient high-level expression is noted in distal lung (AQP4 at postnatal day +2) and trachea (AQP5 at postnatal day +21 and AQP3 at postnatal day +42). In mature animals, AQP5 is abundant in distal lung and salivary glands, AQP3 and AQP4 are present in trachea, and AQP1 is present in all of these tissues except salivary glands. Surprisingly, all four aquaporin proteins are highly abundant in nasopharynx. Unlike AQP1, corticosteroids did not induce expression of AQP3, AQP4, or AQP5 in lung. Our results seemingly implicate aquaporins in proximal airway humidification, glandular secretion, and perinatal clearance of fluid from distal airways. However, the studies underscore a need for detailed immunohistochemical characterizations and definitive functional studies.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Physological Societyen_US
dc.subjectSalivary Glands/physiologyen_US
dc.subjectRespitory Physiological Phenomenaen_US
dc.subjectMembrane Proteinsen_US
dc.subjectLung/physiologyen_US
dc.subjectIon Channels/biosynthesisen_US
dc.subjectAquaporinsen_US
dc.subjectAging/metabolismen_US
dc.titleAquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of raten_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record