Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat

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dc.contributor.author Agre, Peter
dc.contributor.author Nielsen, Søren
dc.contributor.author King, Landon S.
dc.date.accessioned 2010-05-13T18:55:13Z
dc.date.available 2010-05-13T18:55:13Z
dc.date.issued 1997-11
dc.identifier.citation American Journal of Physiology, 1997 Nov;273(5 Pt 1):C1541-8. http://ajpcell.physiology.org/cgi/content/full/273/5/C1541 en
dc.identifier.uri http://jhir.library.jhu.edu/handle/1774.2/34115
dc.description.abstract Developmental expression of aquaporin water transport proteins is not well understood in respiratory tract or secretory glands; here we define aquaporin protein ontogeny in rat. Expression of aquaporin-3 (AQP3), AQP4, and AQP5 proteins occurs within 2 wk after birth, whereas AQP1 first appears before birth. In most tissues, aquaporin protein expression increases progressively, although transient high-level expression is noted in distal lung (AQP4 at postnatal day +2) and trachea (AQP5 at postnatal day +21 and AQP3 at postnatal day +42). In mature animals, AQP5 is abundant in distal lung and salivary glands, AQP3 and AQP4 are present in trachea, and AQP1 is present in all of these tissues except salivary glands. Surprisingly, all four aquaporin proteins are highly abundant in nasopharynx. Unlike AQP1, corticosteroids did not induce expression of AQP3, AQP4, or AQP5 in lung. Our results seemingly implicate aquaporins in proximal airway humidification, glandular secretion, and perinatal clearance of fluid from distal airways. However, the studies underscore a need for detailed immunohistochemical characterizations and definitive functional studies. en
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dc.description.provenance Made available in DSpace on 2010-05-13T18:55:13Z (GMT). No. of bitstreams: 1 AgreAJPLink.pdf: 19432 bytes, checksum: e382ffe476759d066b5ddd07e9df2d73 (MD5) Previous issue date: 1997-11 en
dc.language.iso en_US en
dc.publisher American Physological Society en
dc.subject Salivary Glands/physiology en
dc.subject Respitory Physiological Phenomena en
dc.subject Membrane Proteins en
dc.subject Lung/physiology en
dc.subject Ion Channels/biosynthesis en
dc.subject Aquaporins en
dc.subject Aging/metabolism en
dc.title Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat en
dc.type Article en

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