Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome

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Title: Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome
Author: Ishida, Naruhiro; Agre, Peter; King, Landon S.; Hirai, Shinichiro; Tsubota, Kazuo
Abstract: Dry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of aquaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's syndrome dry eye had the expected apical distribution of AQP5 in lacrimal acinar cells. By contrast, cytoplasmic AQP5 was seen in patients with Sjögren's syndrome. Sodium channel and sodium-potassium ATPase distributions were normal in all groups. These findings show a selective defect in lacrimal gland AQP5 trafficking in Sjögren's syndrome that might contribute to decreased lacrimation and dry eye in these patients.
URI: http://jhir.library.jhu.edu/handle/1774.2/34116
Date: 2001-06-23
Citation: Lancet 2001 Mar 3;357(9257):688-9. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-42P62V0-2B&_user=75682&_coverDate=03%2F03%2F2001&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000006078&_version=1&_urlVersion=0&_userid=75682&md5=57d1ecf81cbe6ead5b0c2efc92dd2821
Subject: Sjogren's Syndrome/metabolism
Membrane Proteins
Lacrimal Apparatus/metabolism
Aquaporins/metabolism

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