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dc.contributor.authorIshida, Naruhiro
dc.contributor.authorAgre, Peter
dc.contributor.authorKing, Landon S.
dc.contributor.authorHirai, Shinichiro
dc.contributor.authorTsubota, Kazuo
dc.date.accessioned2010-05-13T19:06:46Z
dc.date.available2010-05-13T19:06:46Z
dc.date.issued2001-06-23
dc.identifier.citationLancet 2001 Mar 3;357(9257):688-9. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-42P62V0-2B&_user=75682&_coverDate=03%2F03%2F2001&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000006078&_version=1&_urlVersion=0&_userid=75682&md5=57d1ecf81cbe6ead5b0c2efc92dd2821en_US
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/34116
dc.description.abstractDry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of aquaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's syndrome dry eye had the expected apical distribution of AQP5 in lacrimal acinar cells. By contrast, cytoplasmic AQP5 was seen in patients with Sjögren's syndrome. Sodium channel and sodium-potassium ATPase distributions were normal in all groups. These findings show a selective defect in lacrimal gland AQP5 trafficking in Sjögren's syndrome that might contribute to decreased lacrimation and dry eye in these patients.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectSjogren's Syndrome/metabolismen_US
dc.subjectMembrane Proteinsen_US
dc.subjectLacrimal Apparatus/metabolismen_US
dc.subjectAquaporins/metabolismen_US
dc.titleDefective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndromeen_US
dc.typeArticleen_US


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