Browsing JHU Libraries Open Access Fund by Title
Now showing items 1-20 of 46
-
All-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging
(OpticsInfoBase, 2012-10-12)We present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery ... -
Antepartum depression and anxiety associated with disability in African women : cross-sectional results from the CDS Study in Ghana and Cote d’Ivoire
(PLoS Organization, 2012-10-22)Background: Common mental disorders, particularly unipolar depressive disorders, rank among the top 5 with respect to the global burden of disease. As a major public health concern, antepartum depression and anxiety not ... -
APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study
(PLoS Organization, 2013-05-22)The interplay between the innate immune system restriction factor APOBEC3G and the HIV protein Vif is a key host-retrovirus interaction. APOBEC3G can counteract HIV infection in at least two ways: by inducing lethal mutations ... -
Bacterial expression strategies for several Sus scrofa diacylglycerol kinase alpha constructs: solubility challenges.
(Nature Publishing Group, 2013-04-05)We pursued several strategies for expressing either full-length Sus scrofa diacylglycerol kinase (DGK) alpha or the catalytic domain (alphacat) in Escherichia coli. Alphacat could be extracted, refolded, and purified from ... -
Basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome
(Oxford University Press, 2012-06-29)MacroH2A is a histone H2A variant that is typically found in heterochromatic regions of the genome. A positively charged linker that connects the histone-fold with the macro-domain was suggested to have DNA-binding ... -
CD36 and Fyn kinase mediate malaria-induced lung endothelial barrier dysfunction in mice infected with Plasmodium berghei.
(PLoS Organization, 2013-08-15)Severe malaria can trigger acute lung injury characterized by pulmonary edema resulting from increased endothelial permeability. However, the mechanism through which lung fluid conductance is altered during malaria remains ... -
Characterizing optical properties of nano contrast agents by using cross-referencing OCT imaging.
(Optical Society of America, 2013-05-09)We report a cross-referencing method to quickly and accurately characterize the optical properties of nanoparticles including the extinction, scattering, absorption and backscattering cross sections by using an OCT system ... -
Clinical study reports of randomised controlled trials: an exploratory review of previously confidential industry reports
(BMJ Publishing Group, 2013-02-26)OBJECTIVE: To explore the structure and content of a non-random sample of clinical study reports (CSRs) to guide clinicians and systematic reviewers. SEARCH STRATEGY: We searched public sources and lodged Freedom ... -
ClinicalTrials.gov registration can supplement information in abstracts for systematic reviews: a comparisonstudy.
(BioMed Central, 2013-06-18)BACKGROUND: The inclusion of randomized controlled trials (RCTs) reported in conference abstracts in systematic reviews is controversial, partly because study design information and risk of bias is often not fully ... -
Comparison of Sum Absolute QRST Integral, and Temporal Variability in Depolarization and Vectorcardiography Approach, in Healthy Men and Women
(PLoS Organization, 2013-02-22)BACKGROUND: Recently we showed the predictive value of sum absolute QRST integral (SAI QRST) and repolarization lability for risk stratification of sudden cardiac death (SCD) in heart failure patients. The goal of this ... -
Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation.
(PLoS Organization, 2013-06-21)Vascular endothelial growth factor (VEGF) signal transduction is central to angiogenesis in development and in pathological conditions such as cancer, retinopathy and ischemic diseases. However, no detailed mass-action ... -
Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence.
(Nature Publishing Group, 2012-11-14)EGFR is the best studied receptor tyrosine kinase. Yet, a comprehensive mechanistic understanding of EGFR signaling is lacking, despite very active research in the field. In this paper, we investigate the role of the ... -
Cost-effective therapeutic hypothermia treatment device for hypoxic ischemic encephalopathy
(Dove Press, 2012-11-18)Despite recent advances in neonatal care and monitoring, asphyxia globally accounts for 23% of the 4 million annual deaths of newborns, and leads to hypoxic-ischemic encephalopathy (HIE). Occurring in five of 1000 live-born ... -
Cutaneous collateral axonal sprouting re-innervates the skin component and restores sensation of denervated Swine osteomyocutaneous alloflaps.
(PLoS Organization, 2013-10-18)Reconstructive transplantation such as extremity and face transplantation is a viable treatment option for select patients with devastating tissue loss. Sensorimotor recovery is a critical determinant of overall success ... -
Decoupling nucleosome recognition from DNA binding dramatically alters the properties of the Chd1 chromatin remodeler
(Oxford University Press, 2012-12-28)Chromatin remodelers can either organize or disrupt nucleosomal arrays, yet the mechanisms specifying these opposing actions are not clear. Here, we show that the outcome of nucleosome sliding by Chd1 changes dramatically ... -
Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA
(BioMed Central, 2013-03-22)BACKGROUND: The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined ... -
Development of a screening tool to identify female survivors of gender-based violence in a humanitarian setting:qualitative evidence from research among refugees in Ethiopia.
(BioMed Central, 2013-06-12)BACKGROUND: High levels of gender-based violence (GBV) persist among conflict-affected populations and within humanitarian settings and are paralleled by under-reporting and low service utilization. Novel and evidence-based ... -
Differences in Reporting of Analyses in Internal Company Documents Versus Published Trial Reports: Comparisons in Industry-Sponsored Trials in Off-Label Uses of Gabapentin
(PLoS Organization, 2013-01-29)BACKGROUND: Details about the type of analysis (e.g., intent to treat [ITT]) and definitions (i.e., criteria for including participants in the analysis) are necessary for interpreting a clinical trial's findings. Our ... -
ECG marker of adverse electrical remodeling post-myocardial infarction predicts outcomes in MADIT II study
(PLoS Organization, 2012-12-14)Background Post-myocardial infarction (MI) structural remodeling is characterized by left ventricular dilatation, fibrosis, and hypertrophy of the non-infarcted myocardium. Objective The goal of our study was ... -
Epidermal stem cells in orthopaedic regenerative medicine.
(Multidisciplinary Digital Publishing Institute, 2013-05-31)In the last decade, great advances have been made in epidermal stem cell studies at the cellular and molecular level. These studies reported various subpopulations and differentiations existing in the epidermal stem cell. ...