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Decoupling nucleosome recognition from DNA binding dramatically alters the properties of the Chd1 chromatin remodeler
(Oxford University Press, 2012-12-28)
Chromatin remodelers can either organize or disrupt nucleosomal arrays, yet the mechanisms specifying these opposing actions are not clear. Here, we show that the outcome of nucleosome sliding by Chd1 changes dramatically ...
Basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome
(Oxford University Press, 2012-06-29)
MacroH2A is a histone H2A variant that is typically found in heterochromatic regions of the genome. A positively charged linker that connects the histone-fold with the macro-domain was suggested to have DNA-binding ...