Now showing items 1-3 of 3
Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation.
(PLoS Organization, 2013-06-21)
Vascular endothelial growth factor (VEGF) signal transduction is central to angiogenesis in development and in pathological conditions such as cancer, retinopathy and ischemic diseases. However, no detailed mass-action ...
Expression of VEGF and semaphorin genes define subgroups of triple negative breast cancer.
(PLoS Organizaton, 2013-05-08)
Triple negative breast cancers (TNBC) are difficult to treat due to a lack of targets and heterogeneity. Inhibition of angiogenesis is a promising therapeutic strategy, but has had limited effectiveness so far in breast ...
APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study
(PLoS Organization, 2013-05-22)
The interplay between the innate immune system restriction factor APOBEC3G and the HIV protein Vif is a key host-retrovirus interaction. APOBEC3G can counteract HIV infection in at least two ways: by inducing lethal mutations ...