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Improving teaching on an inpatient pediatrics service: a retrospective analysis of a program change
(BioMed Central, 2012-10-01)
Background:
The traditional role of the faculty inpatient attending providing clinical care and effectively teaching residents and medical students is threatened by increasing documentation requirements, pressures to ...
ECG marker of adverse electrical remodeling post-myocardial infarction predicts outcomes in MADIT II study
(PLoS Organization, 2012-12-14)
Background
Post-myocardial infarction (MI) structural remodeling is characterized by left ventricular dilatation, fibrosis, and hypertrophy of the non-infarcted myocardium.
Objective
The goal of our study was ...
Decoupling nucleosome recognition from DNA binding dramatically alters the properties of the Chd1 chromatin remodeler
(Oxford University Press, 2012-12-28)
Chromatin remodelers can either organize or disrupt
nucleosomal arrays, yet the mechanisms specifying
these opposing actions are not clear. Here, we show
that the outcome of nucleosome sliding by Chd1
changes dramatically ...
Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence.
(Nature Publishing Group, 2012-11-14)
EGFR is the best studied receptor tyrosine kinase. Yet, a comprehensive mechanistic understanding of EGFR signaling is lacking, despite very active research in the field. In this paper, we investigate the role of the ...
HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks
(PLoS Organization, 2012-11-15)
BACKGROUND:
Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal stem cell function remain poorly understood. The ...
All-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging
(OpticsInfoBase, 2012-10-12)
We present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery ...
Basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome
(Oxford University Press, 2012-06-29)
MacroH2A is a histone H2A variant that is typically
found in heterochromatic regions of the genome.
A positively charged linker that connects the
histone-fold with the macro-domain was suggested
to have DNA-binding ...
Antepartum depression and anxiety associated with disability in African women : cross-sectional results from the CDS Study in Ghana and Cote d’Ivoire
(PLoS Organization, 2012-10-22)
Background:
Common mental disorders, particularly unipolar depressive disorders, rank among the top 5 with respect to the global burden of disease. As a major public health concern, antepartum depression and anxiety not ...
Cost-effective therapeutic hypothermia treatment device for hypoxic ischemic encephalopathy
(Dove Press, 2012-11-18)
Despite recent advances in neonatal care and monitoring, asphyxia globally accounts for 23% of the 4 million annual deaths of newborns, and leads to hypoxic-ischemic encephalopathy (HIE). Occurring in five of 1000 live-born ...